Abstract
The form-1 antigen of Shigella sonnei was transferred to the avirulent Salmonella typhi strain 21a and the resulting 5076-1C transconjugate strain was tested for safety and immunogenicity as a candidate oral vaccine. The transconjugant strain was shown to be well tolerated and safe in 19 human volunteers who were fed from 1 X 10(7) to 1 X 10(10) organisms. Only two of 10 volunteers tested had developed a rise in antibody titer to the lipopolysaccharide of the hybrid 5076-1C strain.
MeSH terms
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Administration, Oral
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Animals
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Antibodies, Bacterial / analysis
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Antigens, Bacterial / immunology*
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Bacterial Vaccines / immunology*
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Bacterial Vaccines / standards
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Conjugation, Genetic
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Dysentery, Bacillary / prevention & control
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Feces / microbiology
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Female
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Guinea Pigs
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Humans
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Lipopolysaccharides / immunology
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Male
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Plasmids
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Salmonella typhi / genetics
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Salmonella typhi / immunology*
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Shigella sonnei / genetics
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Shigella sonnei / immunology*
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Typhoid Fever / prevention & control
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Typhoid-Paratyphoid Vaccines / immunology*
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Typhoid-Paratyphoid Vaccines / standards
Substances
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Antibodies, Bacterial
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Antigens, Bacterial
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Bacterial Vaccines
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Lipopolysaccharides
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Typhoid-Paratyphoid Vaccines