Abstract
Tri-potassium di-citrato bismuthate given intragastrically to rats 60 min before administration of necrotizing agents such as 85% ethanol, 0.2 N sodium hydroxide or acidified indomethacin, reduced the formation of mucosal lesions dose-dependently. Prostaglandin I2 (PGI2)-like material, determined by bioassay, was higher in the gastric mucosa of animals treated with bismuth subcitrate complex than in control animals.
MeSH terms
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Animals
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Anti-Ulcer Agents*
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Bismuth / pharmacology*
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Epoprostenol / metabolism
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Ethanol / pharmacology
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Gastric Mucosa / drug effects*
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Gastric Mucosa / metabolism
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Indomethacin / pharmacology
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Male
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Organometallic Compounds*
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Rats
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Rats, Inbred Strains
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Sodium Hydroxide / pharmacology
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Stomach Ulcer / chemically induced
Substances
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Anti-Ulcer Agents
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Organometallic Compounds
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Ethanol
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Sodium Hydroxide
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Epoprostenol
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bismuth tripotassium dicitrate
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Bismuth
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Indomethacin