The efficacy of a potassium-sparing combination of chlorthalidone and triamterene in the control of mild and moderate hypertension. I

J Int Med Res. 1984;12(3):133-9. doi: 10.1177/030006058401200301.

Abstract

Chlorthalidone 25 mg/triamterene 50 mg in once-daily oral doses was as effective in reducing blood pressure as chlorthalidone 25 mg alone. The decrease in serum potassium was statistically significantly less with the combination than for chlorthalidone. There were no notable differences between the treatments in any other measure of laboratory safety or adverse reactions.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Chlorthalidone / administration & dosage
  • Chlorthalidone / adverse effects
  • Chlorthalidone / therapeutic use*
  • Clinical Trials as Topic
  • Double-Blind Method
  • Drug Combinations
  • Female
  • Humans
  • Hypertension / drug therapy*
  • Male
  • Middle Aged
  • Potassium / blood*
  • Triamterene / administration & dosage
  • Triamterene / adverse effects
  • Triamterene / therapeutic use*

Substances

  • Drug Combinations
  • Chlorthalidone
  • Potassium
  • Triamterene