Abstract
Aflatoxin B1 (AFB1) causes inhibition of ascorbate-induced and NADPH-dependent lipid peroxidation in hepatic nuclei, Fe2+-stimulated oxidation of linoleic acid is also inhibited by AFB1. The inhibition of lipid peroxidation by AFB1 is independent of its metabolism in nuclei and probably due to the anti-oxidant property of AFB1.
MeSH terms
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Aflatoxin B1
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Aflatoxins / pharmacology*
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Animals
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Ascorbic Acid / pharmacology*
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Brain / metabolism
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Cell Nucleus / metabolism*
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Guinea Pigs
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In Vitro Techniques
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Lipid Peroxides / biosynthesis*
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Liver / drug effects
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Liver / metabolism*
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Male
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Malondialdehyde / metabolism
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NADP / metabolism*
Substances
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Aflatoxins
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Lipid Peroxides
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Malondialdehyde
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NADP
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Aflatoxin B1
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Ascorbic Acid