The myxalamids, new antibiotics from Myxococcus xanthus (Myxobacterales). I. Production, physico-chemical and biological properties, and mechanism of action

J Antibiot (Tokyo). 1983 Sep;36(9):1150-6. doi: 10.7164/antibiotics.36.1150.

Abstract

From the cell mass and culture supernatant of Myxococcus xanthus strain Mx X12 an antibiotic activity against yeasts, molds and some Gram-positive bacteria could be extracted. It consisted of 4 biologically active compounds which were named myxalamid A, B, C and D. The main component, myxalamid B, was shown to block in beef heart submitochondrial particles the respiratory chain at the site of complex I, i.e. NADH: ubiquinone oxidoreductase. The myxalamids are new antibiotics.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Anti-Bacterial Agents / isolation & purification*
  • Bacteria / drug effects
  • Cattle
  • Cytochromes / metabolism
  • Drug Evaluation, Preclinical
  • Fungi / drug effects
  • Microbial Sensitivity Tests
  • Mitochondria, Heart / drug effects
  • Mitochondria, Heart / metabolism
  • Myxococcales / growth & development*
  • NAD / metabolism
  • Oxidation-Reduction
  • Polyenes / isolation & purification
  • Polyenes / toxicity
  • Spectrophotometry, Infrared
  • Structure-Activity Relationship
  • Submitochondrial Particles / drug effects
  • Submitochondrial Particles / metabolism

Substances

  • Anti-Bacterial Agents
  • Cytochromes
  • Polyenes
  • NAD
  • myxalamid A
  • myxalamid B
  • myxalamid C
  • myxalamid D