Abstract
From the culture supernatant of the myxobacterium, Myxococcus fulvus strain Mx f50, an antibiotic activity was isolated which blocked growth of many Gram-positive and several Gram-negative bacteria, but not of yeasts and fungi. The activity consisted of two closely related compounds, myxopyronins A and B. The myxopyronins appear to be new antibiotics, and seem to specifically inhibit bacterial RNA polymerase.
MeSH terms
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Animals
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Anti-Bacterial Agents / toxicity*
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Gram-Negative Bacteria / drug effects
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Gram-Positive Bacteria / drug effects
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Kinetics
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Lactones / isolation & purification
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Lactones / toxicity*
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Mice
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Microbial Sensitivity Tests
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Myxococcales / growth & development*
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Staphylococcus aureus / drug effects
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Staphylococcus aureus / genetics
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Transcription, Genetic / drug effects*
Substances
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Anti-Bacterial Agents
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Lactones
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myxopyronin A
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myxopyronin B