Abstract
The synthesis of 6-amino-1H-pyrrolo[3,2-c]pyridin-4(5H)-one (3,7-dideazaguanine, 2) has been accomplished from 3-(ethoxycarbonyl)pyrrole-2-acetonitrile. In contrast to 3-deazaguanine, compound 2 did not show any antitumor, antiviral, or antibacterial properties. Furthermore, it was not a substrate for hypoxanthine-guanine phosphoribosyltransferase or purine nucleoside phosphorylase.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Anti-Bacterial Agents
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Anti-Infective Agents / chemical synthesis*
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Cell Division / drug effects
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Cell Line
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Cricetinae
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Cricetulus
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Erythrocytes / enzymology
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Escherichia coli / drug effects
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Female
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Guanine / analogs & derivatives*
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Guanine / chemical synthesis
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Guanine / pharmacology
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Guanine / toxicity
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Humans
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Hypoxanthine Phosphoribosyltransferase / blood
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Indicators and Reagents
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Microbial Sensitivity Tests
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Ovary
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Purine-Nucleoside Phosphorylase / blood
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Structure-Activity Relationship
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Viruses / drug effects
Substances
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Anti-Bacterial Agents
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Anti-Infective Agents
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Indicators and Reagents
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Guanine
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3,7-dideazaguanine
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Purine-Nucleoside Phosphorylase
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Hypoxanthine Phosphoribosyltransferase