Abstract
We evaluated a combination of various antineoplastic drugs used in vitrectomy infusion fluid for toxicity. A combination of 250 micrograms/ml of 5-fluorouracil with each of the following agents, 8.0 micrograms/ml of thiotepa or 40 micrograms/ml of etoposide, or 0.1 micrograms/ml doxorubicin, or 0.1 microgram/ml vincristine was tolerated well in the rabbit eyes.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Antineoplastic Combined Chemotherapy Protocols / toxicity*
-
Doxorubicin / toxicity
-
Etoposide / toxicity
-
Fluorouracil / toxicity
-
Ophthalmic Solutions / toxicity*
-
Rabbits
-
Thiotepa / toxicity
-
Vincristine / toxicity
-
Vitrectomy*
Substances
-
Ophthalmic Solutions
-
Vincristine
-
Etoposide
-
Doxorubicin
-
Thiotepa
-
Fluorouracil