Abstract
Antiserum to the myelin lipid galactocerebroside (GalC) causes rapidly progressive focal demyelination when injected into guinea pig optic nerves. The capacity of anti-GalC to induce central nervous system demyelination is complement-dependent, and demyelinating activity is present in the immunoglobulin fraction of anti-GalC serum. Demyelination appears to result from primary damage to oligodendrocytes.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cerebrosides / immunology*
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Female
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Galactosylceramides / immunology*
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Guinea Pigs
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Immune Sera / pharmacology*
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Microscopy, Electron
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Myelin Sheath / drug effects*
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Nerve Fibers, Myelinated / drug effects
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Oligodendroglia / drug effects
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Optic Nerve / drug effects*
Substances
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Cerebrosides
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Galactosylceramides
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Immune Sera
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galactocerebroside