Abstract
Hoe 263 inhibited the contraction of the potassium-depolarized pulmonary artery of the guinea pig. In this experiment it was slightly more active than verapamil. The calcium uptake of the potassium-depolarized pulmonary artery was inhibited by Hoe 263 more effectively than by prenylamine. The upstroke velocity of the potassium-depolarized papillary muscle of the guinea pig was depressed with similar concentrations of Hoe 263 and verapamil. In the (3H)-nitrendipine binding test, Hoe 263 was effective at similar concentrations as prenylamine and verapamil. The positive inotropic effect of K-strophanthin was depressed by Hoe 263 at concentrations which were comparable with those necessary for verapamil.
MeSH terms
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Animals
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Benzhydryl Compounds / pharmacology*
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Calcium Channel Blockers*
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Calcium Radioisotopes
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Cymarine / pharmacology
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Dogs
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Guinea Pigs
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In Vitro Techniques
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Membranes / metabolism
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Muscle Contraction / drug effects
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Muscle, Smooth, Vascular / drug effects
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Myocardium / metabolism
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Neuromuscular Depolarizing Agents
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Nifedipine / analogs & derivatives
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Nifedipine / metabolism
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Nitrendipine
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Papillary Muscles / metabolism
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Potassium / pharmacology
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Prenylamine / pharmacology
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Pulmonary Artery / drug effects
Substances
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Benzhydryl Compounds
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Calcium Channel Blockers
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Calcium Radioisotopes
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Neuromuscular Depolarizing Agents
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N-(2-benzhydryloxy)ethyl-N-methyl-(1-ethyl-2-(3-methoxyphenyl)ethyl)amine
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Nitrendipine
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Nifedipine
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Prenylamine
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Potassium
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Cymarine