Creatine kinase isoenzymes in serum from children--especially focusing on CK-BB

Scand J Clin Lab Invest. 1984 Sep;44(5):429-32. doi: 10.3109/00365518409083833.

Abstract

In 161 children with ages ranging from 7 months to 18 years the concentration of CK-BB in serum was measurable in 58%. The activity in serum of CK-BB (cCK-BB(S] in children varies with age and is not significantly influenced by seizure, epilepsy or body temperature. The values are most elevated during the first year of life and show a rapid fall, never reaching adult levels. Comparing mean cCK-BB(S) values in children to growth charts the resemblance is striking. CK-BB is the only CK-isoenzyme that changes with age. We postulate that cCK-BB(S) is related to growth as a physiological phenomenon. CK-MB was found in serum in 7% of the children and could not be of cardiac origin. Therefore CK-MB cannot be regarded as cardiac specific in children.

MeSH terms

  • Adolescent
  • Age Factors
  • Body Temperature
  • Child
  • Child, Preschool
  • Creatine Kinase / blood*
  • Growth
  • Humans
  • Infant
  • Isoenzymes
  • Reference Values
  • Seizures / enzymology

Substances

  • Isoenzymes
  • Creatine Kinase