[Scintigraphic diagnosis of multiple pheochromocytomas in childhood with 131I-m-benzylguanidine]

Monatsschr Kinderheilkd. 1984 Oct;132(10):791-6.
[Article in German]

Abstract

Scintigraphy with 131I-m-BG was used in 4 children with a history of multiple pheochromocytomas in order to localize further catecholamine-producing tumors prior to surgery. We overlook 7 scintigraphies without any side effect. Phenoxybenzamine did not interfere with tracer uptake into tumors. Scintigraphic localization of even smallest extra-adrenal tumors was successful in all cases. In most cases we were dealing with benign pheochromocytomas, but also a ganglioneuroma and metastases of a malignant pheochromocytoma could be revealed. Scintigraphy is a reliable technique for tracing pheochromocytomas and catecholamine-producing ganglioneuromas. It seems to be superior to other non-invasive techniques, furthermore, invasive techniques bearing higher risks may be suspended.

Publication types

  • Case Reports

MeSH terms

  • 3-Iodobenzylguanidine
  • Adolescent
  • Adrenal Gland Neoplasms / diagnostic imaging*
  • Adrenal Gland Neoplasms / surgery
  • Adrenalectomy
  • Catecholamines / urine
  • Child
  • Diagnosis, Differential
  • Female
  • Ganglioneuroma / diagnostic imaging
  • Ganglioneuroma / surgery
  • Humans
  • Iodine Radioisotopes
  • Iodobenzenes*
  • Male
  • Neoplasms, Multiple Primary / diagnostic imaging*
  • Neoplasms, Multiple Primary / surgery
  • Pheochromocytoma / diagnostic imaging*
  • Pheochromocytoma / surgery
  • Postoperative Complications / diagnostic imaging
  • Radionuclide Imaging
  • Reoperation
  • Sympatholytics*

Substances

  • Catecholamines
  • Iodine Radioisotopes
  • Iodobenzenes
  • Sympatholytics
  • 3-Iodobenzylguanidine