Abstract
Four new derivatives of 1,2,3,4-tetrahydro-beta-carboline 2a--d were synthetized with the pyridoxal moiety in position 1; there were also obtained four Schiff bases 1a--d which are intermediate products in this synthesis. Schiff bases 1a--d revealed a sedative and analgesic action, and compound 1b also had potential antidepressive properties. The derivatives of tetrahydro-beta-carboline 2a--d were inactive in the carried out tests.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Analgesics / chemical synthesis
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Animals
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Antidepressive Agents / chemical synthesis
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Blepharoptosis / chemically induced
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Body Temperature / drug effects
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Chemical Phenomena
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Chemistry
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Drug Synergism
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Lethal Dose 50
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Levodopa / pharmacology
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Male
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Mice
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Motor Activity / drug effects
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Pyridoxal / analogs & derivatives*
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Pyridoxal / pharmacology
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Pyridoxal / toxicity
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Reserpine / antagonists & inhibitors
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Schiff Bases / chemical synthesis
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Seizures / chemically induced
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Tryptamines / chemical synthesis*
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Tryptamines / pharmacology
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Tryptamines / toxicity
Substances
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Analgesics
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Antidepressive Agents
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Schiff Bases
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Tryptamines
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Pyridoxal
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Levodopa
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Reserpine