The analysis of 309 Hodgkin patients treated by radiotherapy alone or in association with chemotherapy, between 1969 and 1979, has shown seven cases of ANLL (acute non lymphoblastic leukemia). The incidence was 2.26% in the overall group and 3.38% in the patients treated with combined therapies. From the frequency and distribution of ANLL in the various treatment groups we can argue that: ANLL may be considered as a second, therapy-induced tumor, correlated with the association of chemotherapy and radiotherapy.