Abstract
The concentration of DL-8280, a new pyridone carboxylic acid, in the prostatic tissue and fluid after oral administration to man was studied. The drug was concentrated in the prostate and the concentration was dose-dependent. The ratios of prostatic tissue and fluid levels to serum levels were 1.62-1.79 and 1.65-1.96. respectively.
MeSH terms
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Administration, Oral
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Aged
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Anti-Infective Agents / administration & dosage
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Anti-Infective Agents / metabolism*
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Body Fluids / metabolism*
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Dose-Response Relationship, Drug
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Humans
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Male
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Middle Aged
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Ofloxacin
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Oxazines / administration & dosage
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Oxazines / metabolism*
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Prostate / metabolism*
Substances
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Anti-Infective Agents
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Oxazines
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Ofloxacin