Abstract
Synthesis of a series of 3-hydroxynaphthalene-2-carbonylamino acid methyl esters (II-XI) and some of their corresponding hydrazides (XII-XXI), dipeptide methyl esters (XXII-XXXV) and dipeptide hydrazides (XXXVI-XXXIX) is described. 3-Hydroxynaphthalene-2-CO-L-Tyr-N2H3 (XX) and the corresponding L-Val-L-Ala-N2H3 (XXXVI) were found to be active against a number of micro-organisms.
MeSH terms
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Amino Acids / chemical synthesis*
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Amino Acids / pharmacology
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Anti-Bacterial Agents
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Anti-Infective Agents / chemical synthesis*
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Bacteria / drug effects
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Chemical Phenomena
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Chemistry
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Dipeptides / chemical synthesis*
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Dipeptides / pharmacology
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Fungi / drug effects
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Naphthols / chemical synthesis*
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Naphthols / pharmacology
Substances
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Amino Acids
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Anti-Bacterial Agents
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Anti-Infective Agents
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Dipeptides
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Naphthols