Abstract
Twenty four hours after intraperitoneal injection of alkylating agents, N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), N-methyl-N-nitrosourea (MNU) and methyl methanesulfonate (MMS), into rats, an increase in nicotinamide (Nmd) methyltransferase and N1-methylnicotinamide (1-CH3Nmd) oxidase activities in the liver was found. Since activities of these enzymes in the liver extracts were not stimulated directly by these agents in vitro, it is postulated that the increases in these enzyme activities are due to the induction of each enzyme.
MeSH terms
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Aldehyde Oxidase
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Aldehyde Oxidoreductases / analysis*
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Alkylating Agents / pharmacology*
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Animals
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Chromatography, Thin Layer
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Enzyme Induction
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Humans
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Liver / enzymology*
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Methyl Methanesulfonate / pharmacology
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Methylnitronitrosoguanidine / pharmacology
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Methylnitrosourea / pharmacology
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Methyltransferases / analysis*
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Nicotinamide N-Methyltransferase
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Rats
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Rats, Inbred Strains
Substances
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Alkylating Agents
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Methylnitronitrosoguanidine
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Methylnitrosourea
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Methyl Methanesulfonate
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Aldehyde Oxidoreductases
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N1-methylnicotinamide oxidase II
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Aldehyde Oxidase
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Methyltransferases
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Nicotinamide N-Methyltransferase