Abstract
The hypothalamic-pituitary-adrenal (HPA) axis function of eight patients with rheumatoid arthritis receiving regular intra-articular methyl prednisolone acetate was studied. Tests of the HPA axis 5-7 weeks after the last injection revealed suppression in two patients. Some patients receiving intra-articular corticosteroids may therefore have abnormal responses to stress.
MeSH terms
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Aged
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Anti-Inflammatory Agents / therapeutic use*
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Arthritis, Rheumatoid / drug therapy*
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Depression, Chemical
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Female
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Humans
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Hydrocortisone / metabolism
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Hypothalamo-Hypophyseal System / drug effects*
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Hypothalamo-Hypophyseal System / metabolism
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Male
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Methylprednisolone / analogs & derivatives*
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Methylprednisolone / therapeutic use
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Methylprednisolone Acetate
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Middle Aged
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Pituitary-Adrenal System / drug effects*
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Pituitary-Adrenal System / metabolism
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Time Factors
Substances
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Anti-Inflammatory Agents
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Methylprednisolone Acetate
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Hydrocortisone
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Methylprednisolone