Abstract
Seven atopic and 6 nonatopic asthmatics with exercise-induced asthma were subjected to a treadmill exercise task. After this procedure, both groups had elevations in the concentrations of plasma histamine and serum high molecular weight neutrophil chemotactic activity (as assessed by Sephadex G-200 chromatography). These findings support the view that the release of mast-cell-associated mediators can be independent of the atopic state.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Asthma / immunology*
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Asthma, Exercise-Induced / immunology*
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Asthma, Exercise-Induced / physiopathology
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Chemotaxis, Leukocyte*
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Chromatography, Gel
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Female
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Histamine / blood*
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Humans
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Hypersensitivity, Immediate / immunology*
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Hypersensitivity, Immediate / physiopathology
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Immunoglobulin E / analysis
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Male
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Middle Aged
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Neutrophils / immunology
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Peak Expiratory Flow Rate
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Time Factors
Substances
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Immunoglobulin E
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Histamine