8 patients suffering from multiple sclerosis were treated with plasmapheresis. Other methods of management such as cortisone or azathioprine therapy were discontinued one month before plasmapheresis. The patients were investigated before, and on the 1st, 2nd and 3rd day after plasmapheresis using the Kurtzke Disability Score and the Hamilton Rating Scale. No improvement in neurological or psychiatric symptoms or signs was detected following plasmapheresis.