Abstract
The efficacy of PALA was evaluated in 22 patients with metastatic soft tissue and bone sarcomas. The 20 evaluable patients had received a median of three prior chemotherapeutic regimens, including an adriamycin combination, to which eight had shown response. PALA was administered at 2-week intervals. Sixteen patients received 6 g/m2 over 1 hour intravenously as their initial dose, while six patients received 5 g/m2. The major side effects were skin rash, stomatitis, diarrhea, nausea, and vomiting. Significant myelosuppression was not seen. Two patients had stabilization of disease for periods of 10 and 13 weeks. At the dose and schedule used in this trial, PALA was not effective against advanced adult sarcoma.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Aged
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Antimetabolites, Antineoplastic / adverse effects
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Antimetabolites, Antineoplastic / therapeutic use*
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Aspartic Acid / adverse effects
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Aspartic Acid / analogs & derivatives*
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Aspartic Acid / therapeutic use
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Bone Neoplasms / drug therapy*
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Diarrhea / chemically induced
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Drug Evaluation
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Female
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Humans
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Male
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Middle Aged
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Organophosphorus Compounds / therapeutic use*
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Phosphonoacetic Acid / adverse effects
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Phosphonoacetic Acid / analogs & derivatives
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Phosphonoacetic Acid / therapeutic use*
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Sarcoma / drug therapy*
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Sarcoma / secondary
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Skin Diseases / chemically induced
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Soft Tissue Neoplasms / drug therapy*
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Stomatitis / chemically induced
Substances
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Antimetabolites, Antineoplastic
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Organophosphorus Compounds
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Aspartic Acid
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sparfosic acid
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Phosphonoacetic Acid