Myxothiazol, an antibiotic from Myxococcus fulvus (myxobacterales). I. Cultivation, isolation, physico-chemical and biological properties

J Antibiot (Tokyo). 1980 Dec;33(12):1474-9. doi: 10.7164/antibiotics.33.1474.

Abstract

Myxothiazol (AB-Mx f16-1), a new antifungal antibiotic, is produced by the myxobacterium Myxococcus fulvus strain Mx f16. It is active against many filamentous fungi, and completely inhibits growth of Mucor hiemalis at a concentration of 2 micrograms/ml. The molecular formula of myxothiazol was determined to e C25H33N3O3S2.

MeSH terms

  • Animals
  • Antifungal Agents / biosynthesis*
  • Antifungal Agents / isolation & purification
  • Antifungal Agents / pharmacology
  • Chemical Phenomena
  • Chemistry
  • Chemistry, Physical
  • Chick Embryo
  • Drug Resistance, Microbial
  • Fermentation
  • Fungi / drug effects
  • Methacrylates
  • Mice
  • Myxococcales / metabolism*
  • Thiazoles / biosynthesis
  • Thiazoles / isolation & purification
  • Thiazoles / pharmacology

Substances

  • Antifungal Agents
  • Methacrylates
  • Thiazoles
  • myxothiazol