A human cell-surface antigen defined by a monoclonal antibody and controlled by a gene on chromosome 12

Somatic Cell Genet. 1981 Jul;7(4):435-43. doi: 10.1007/BF01542988.

Abstract

A murine monoclonal antibody 602-29, subclass IgG1, that recognizes an antigenic determinant expressed by most human cells is described. Immunoprecipitation and sodium dodecyl sulfate-gel electrophoresis analysis indicate that the antigenic determinant is carried by a protein with an apparent molecular weight of 21,000. The antigen is expressed by human-mouse somatic cell hybrids, and analysis of segregants that have lost human chromosomes indicates that the gene controlling expression of the 602-29 antigen is on chromosome 12.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibodies, Monoclonal / immunology
  • Antigens, Surface / genetics*
  • Antigens, Surface / immunology
  • Cell Line
  • Chromosomes, Human, 6-12 and X / ultrastructure*
  • Fibrosarcoma / immunology*
  • Genetic Linkage
  • Humans
  • Immunodiffusion
  • Immunosorbent Techniques
  • Mice
  • Teratoma / immunology*

Substances

  • Antibodies, Monoclonal
  • Antigens, Surface