Angioimmunoblastic lymphadenopathy with paraproteinemia: a T- and B-cell disorder

A Klajman; A Yaretzky; M Schneider; Y Holoshitz; A Shneur; B Griffel

doi:10.1002/1097-0142(19811201)48:11<2433::aid-cncr2820481116>3.0.co;2-u

Angioimmunoblastic lymphadenopathy with paraproteinemia: a T- and B-cell disorder

Cancer. 1981 Dec 1;48(11):2433-7. doi: 10.1002/1097-0142(19811201)48:11<2433::aid-cncr2820481116>3.0.co;2-u.

Authors

A Klajman, A Yaretzky, M Schneider, Y Holoshitz, A Shneur, B Griffel

Abstract

A case is reported of angioimmunoblastic lymphadenopathy (AILD), in which a IgM Kappa monoclonal gammopathy developed. On the first admission the immunoblasts were shown to be T cells by surface-marker studies. Although the number of circulating T cells was normal, their functional capacities were markedly reduced. The patient was followed for two months at the end of which she died with hematologic features of immunoblastic plasma cell leukemia.

Publication types

Case Reports

MeSH terms

Agammaglobulinemia / etiology
Agammaglobulinemia / immunology
Aged
Antibodies, Monoclonal / immunology
B-Lymphocytes / immunology
Female
Humans
Immunoblastic Lymphadenopathy / complications
Immunoblastic Lymphadenopathy / immunology*
Immunoglobulin M / immunology
Immunoglobulin kappa-Chains / immunology
Leukemia, Plasma Cell / etiology
Lymphocyte Activation
Paraproteinemias / immunology
Rosette Formation
T-Lymphocytes / immunology

Substances

Antibodies, Monoclonal
Immunoglobulin M
Immunoglobulin kappa-Chains