Blockade of 3-carbomethoxy-beta-carboline induced seizures by diazepam and the benzodiazepine antagonists, Ro 15-1788 and CGS 8216

Pharmacol Biochem Behav. 1982 Sep;17(3):457-60. doi: 10.1016/0091-3057(82)90304-5.

Abstract

The benzodiazepine antagonists Ro 15-1788 and CGS 8216 blocked the clonic and tonic convulsions elicited by 3-carbomethoxy-beta-carboline (beta-CCM). The PD50 values for Ro 15-1788, CGS 8216, and diazepam were: 2.0, 0.6, and 2.0 mg/kg, respectively. Neither Ro 15-1788 nor CGS 8216 potentiated the effect of a threshold convulsant dose of beta-CCM. Moreover, these benzodiazepine antagonists neither attenuated nor potentiated the tremorigenic actions of another beta-carboline, harmaline. Diazepam, however, considerably reduced the tremorigenic actions of this drug.

MeSH terms

  • Animals
  • Benzodiazepinones / pharmacology*
  • Carbolines / antagonists & inhibitors*
  • Convulsants / antagonists & inhibitors*
  • Diazepam / pharmacology*
  • Dose-Response Relationship, Drug
  • Flumazenil
  • Harmaline / pharmacology
  • Indoles / antagonists & inhibitors*
  • Male
  • Mice
  • Pyrazoles / pharmacology*
  • Seizures / chemically induced
  • Seizures / prevention & control*
  • Tremor / chemically induced

Substances

  • Benzodiazepinones
  • Carbolines
  • Convulsants
  • Indoles
  • Pyrazoles
  • Flumazenil
  • 2-phenylpyrazolo(4,3-c)quinolin-3(5H)-one
  • Harmaline
  • beta-carboline-3-carboxylic acid methyl ester
  • Diazepam