Tumor promoting activity of 1,8-dihydroxy-3-methyl-9-anthrone (chrysarobin) in female SENCAR mice

Carcinogenesis. 1983;4(3):281-4. doi: 10.1093/carcin/4.3.281.

Abstract

Purified 1,8-dihydroxy-3-methyl-9-anthrone or chrysarobin was found to be an effective skin tumor-promoter in SENCAR mice, although, at the dose used, it was approximately 43-fold less active than 12-O-tetradecanoylphorbol-13-acetate (TPA). When non-promoting doses of chrysarobin were applied 30 min prior to each application of TPA, a marked potentiation in the promoting response to TPA was observed. Chrysarobin will provide a valuable tool for studying the mechanism of action of anthracene-derived mouse skin tumor promoters.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Anthracenes / toxicity*
  • Carcinogens / toxicity*
  • Female
  • Mice
  • Mice, Inbred Strains
  • Neoplasms, Experimental / pathology
  • Papilloma / chemically induced
  • Papilloma / pathology
  • Skin Neoplasms / chemically induced*
  • Skin Neoplasms / pathology
  • Tetradecanoylphorbol Acetate

Substances

  • Anthracenes
  • Carcinogens
  • chrysarobin
  • Tetradecanoylphorbol Acetate