The argon laser offers several theoretical advantages over excision, electrocautery, or CO2 laser therapy for the treatment of peritoneal implants of endometriosis. Therefore, a study of the feasibility of the argon laser for the treatment of endometriosis was performed using five virgin New Zealand White rabbits. Following 6 days of estrogen administration, each animal underwent laparotomy with excision of the right uterine horn. Sections of endometrium were sutured to several peritoneal surfaces. Approximately 3 weeks later the endometrial implants were photocoagulated with the argon laser (488 nm, 2 W, 2-mm spot size, 3 to 5 seconds). Histologic examination of the sites of laser therapy demonstrated complete ablation of the endometriosis with 0.25-mm damage to the underlying tissue and surrounding tissue.