Abstract
A case of myelodysplasia (refractory anaemia with excessive blasts) arising 7 years after a 3 year period of intermittent monthly treatment cycles with melphalan for multiple myelomas is reported. This is another example of preleukaemic syndrome possibly caused by melphalan. Among the possible pathogenetic mechanisms, the incidence of cyclic episodes of medullary hypoplasia are emphasised.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Blood Transfusion
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Erythrocyte Transfusion
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Female
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Humans
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Melphalan / adverse effects
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Melphalan / therapeutic use*
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Middle Aged
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Multiple Myeloma / drug therapy*
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Myeloproliferative Disorders / chemically induced*
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Myeloproliferative Disorders / therapy
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Platelet Transfusion
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Prednisone / therapeutic use
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Preleukemia / therapy
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Time Factors