Toxicity investigation of fenbendazole, an anthelmintic of swine

Am J Vet Res. 1983 Jun;44(6):1108-11.

Abstract

The toxicity of fenbendazole, an anthelmintic for use in swine, was tested by feeding 8 growing pigs 2,000 mg of fenbendazole/kg of body weight daily for 14 days. A transient leukopenia developed on day 6, but values returned to base line on day 18, 4 days after discontinuation of dosing. Sorbitol dehydrogenase values were significantly (P less than 0.05) increased from day 4 and returned to base line on day 20. Marked gross or histopathologic lesions were not found.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaline Phosphatase / analysis
  • Animals
  • Benzimidazoles / toxicity*
  • Female
  • Fenbendazole / toxicity*
  • L-Iditol 2-Dehydrogenase / analysis
  • Leukopenia / chemically induced
  • Swine*

Substances

  • Benzimidazoles
  • Fenbendazole
  • L-Iditol 2-Dehydrogenase
  • Alkaline Phosphatase