Safety of fenbendazole in swine

Am J Vet Res. 1983 Jun;44(6):1112-6.

Abstract

The safety of fenbendazole, an anthelmintic for use in swine, was tested by feeding 0, 25, 75, or 125 mg of fenbendazole/kg of body weight for 5 days. A dose-related transient leukopenia developed on day 7, but values returned to base line on day 15. In the groups fed 75 or 125 mg, sorbitol dehydrogenase activity increased on day 3 but returned to base line on day 10. Significant gross or histopathologic lesions were not found.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Benzimidazoles / toxicity*
  • Blood / drug effects
  • Female
  • Fenbendazole / toxicity*
  • L-Iditol 2-Dehydrogenase / analysis
  • Leukocyte Count
  • Phosphorus / blood
  • Swine* / blood

Substances

  • Benzimidazoles
  • Phosphorus
  • Fenbendazole
  • L-Iditol 2-Dehydrogenase