Histocompatibility determinants in Israeli Jewish patients with coeliac disease: population and family study

Tissue Antigens. 1981 Mar;17(3):313-22. doi: 10.1111/j.1399-0039.1981.tb00706.x.

Abstract

The association between HLA and coeliac disease (CD) was studied in the Jewish population of Israel. A total of 112 patients were typed for HLA-A,B,C antigens, including 67 patients whose families were typed in order to deduce the genotypes. Forty-seven patients were typed for HLA-DR antigens. The HLA-A,B,C data show a pattern of association, which is similar to that found in European CD patients: HLA-B8 is increased, although to a lower degree; a suggestive, insignificant increase for Aw30, B13 and Cw6 and a decrease of Bw35 were noted. The DR antigens DR3 and DR7 are associated with CD in the Jewish population. An excess of DR3/DR7 heterozygotes was noted. The data from family and population studies support a model in which two different HLA-DR associated genes are interacting.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Celiac Disease / genetics
  • Celiac Disease / immunology*
  • Diabetes Mellitus, Type 1 / genetics
  • Diabetes Mellitus, Type 1 / immunology
  • Family Health*
  • Family*
  • Gene Frequency
  • HLA Antigens / genetics*
  • Haploidy
  • Histocompatibility Antigens Class II / genetics
  • Humans
  • Israel
  • Jews
  • Meiosis
  • Phenotype
  • Population*

Substances

  • HLA Antigens
  • Histocompatibility Antigens Class II