Abstract
The HLA antigens of 173 patients with the congenital rubella syndrome (CR) are reported. Twenty-one of these patients are also clinically diabetic, and among them the frequencies of the HLA antigens DR2 and DR3 are significantly lower and higher, respectively, than in CR patients without diabetes or in controls. These data suggest that the genes that control susceptibility to type I or insulin-dependent diabetes mellitus are necessary for the development of glucose intolerance in CR patients.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adolescent
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Adult
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Child
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Child, Preschool
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Deafness / complications
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Diabetes Mellitus, Type 1 / complications
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Diabetes Mellitus, Type 1 / immunology*
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Eye Diseases / complications
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HLA Antigens / analysis*
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HLA-B Antigens
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HLA-DR Antigens
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Histocompatibility Antigens Class II / analysis
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Humans
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Infant
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Intellectual Disability / complications
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Rubella / complications
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Rubella / congenital*
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Syndrome
Substances
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HLA Antigens
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HLA-B Antigens
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HLA-DR Antigens
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Histocompatibility Antigens Class II