Abstract
N-aminoalkyl derivatives of 2-pyrrolidinone (1-5) and methylene-bis-amino derivatives (7-9) as intermediary products formed during aminoalkylation were described. Compounds 2 and 3, in doses over 30 and 20 mg/kg resp., displayed analgesic properties; compound 3 exerted also a weak anti-inflammatory action (37 mg/kg po) in the carrageenin test.
MeSH terms
-
5-Hydroxytryptophan / pharmacology
-
Amines / chemical synthesis*
-
Analgesics / chemical synthesis
-
Animals
-
Anti-Inflammatory Agents
-
Anticonvulsants / chemical synthesis
-
Antidepressive Agents / chemical synthesis
-
Behavior, Animal / drug effects
-
Chemical Phenomena
-
Chemistry
-
Lethal Dose 50
-
Male
-
Mannich Bases / chemical synthesis*
-
Mannich Bases / pharmacology
-
Mice
-
Motor Activity / drug effects
-
Pyrrolidinones / chemical synthesis*
-
Pyrrolidinones / pharmacology
-
Rats
-
Rats, Inbred Strains
Substances
-
Amines
-
Analgesics
-
Anti-Inflammatory Agents
-
Anticonvulsants
-
Antidepressive Agents
-
Mannich Bases
-
Pyrrolidinones
-
5-Hydroxytryptophan