Abstract
It was established in experiments on mice and rats carried out according to conventional procedures that 13 adamantane derivatives have a greater tranquilizing activity than amantadine, 3-bromadamantoyl-1 diazomethane exerting a stronger effect than trioxazin. Two adamantane derivatives were found to have an anticonvulsant activity.
Publication types
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Comparative Study
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English Abstract
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Review
MeSH terms
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Adamantane / analogs & derivatives*
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Adamantane / toxicity
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Animals
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Conditioning, Classical / drug effects
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Escape Reaction / drug effects
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Female
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Humans
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Lethal Dose 50
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Male
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Mice
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Muscle Relaxation / drug effects
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Orientation / drug effects
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Pentylenetetrazole / antagonists & inhibitors
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Rats
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Sleep / drug effects
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Tranquilizing Agents*
Substances
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Tranquilizing Agents
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Adamantane
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Pentylenetetrazole