Abstract
The effect of captopril on intralymphocytic sodium concentration in hypertensive subjects was studied. After acute and chronic treatment the intralymphocytic sodium content decreased. The possibility is discussed that a similar decrease might also occur in smooth muscle cells, thus enhancing the hypotensive effect of captopril.
MeSH terms
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Adult
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Aldosterone / blood
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Blood Pressure / drug effects
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Captopril / therapeutic use*
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Humans
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Hypertension / blood
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Hypertension / drug therapy*
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Lymphocytes / drug effects*
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Lymphocytes / metabolism
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Middle Aged
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Potassium / blood
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Proline / analogs & derivatives*
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Renin / blood
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Sodium / blood*
Substances
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Aldosterone
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Proline
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Captopril
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Sodium
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Renin
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Potassium