Abstract
Some of the central and peripheral effects of oxotremorine (OT) and its azetidine analogue, N-[4-azetidinyl)-2-butynyl]-2-pyrrolidone (BM 120), were compared in mice and rats. BM 120 was found to be about twice as potent as OT and to have a somewhat longer duration of action. All its effects were antagonized by pretreatment with atropine sulphate. BM 120 acted as powerful muscarinic agonist on the isolated guinea pig ileum.
MeSH terms
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Animals
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Body Temperature / drug effects
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Dose-Response Relationship, Drug
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Guinea Pigs
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Ileum / drug effects
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In Vitro Techniques
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Male
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Mice
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Mice, Inbred Strains
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Muscle Contraction / drug effects
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Oxotremorine / analogs & derivatives*
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Oxotremorine / metabolism
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Oxotremorine / pharmacology*
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Parasympathomimetics / pharmacology*
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Rats
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Rats, Inbred Strains
Substances
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N-(4-(1-azetidinyl)-2-butynyl)-2-pyrrolidone
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Parasympathomimetics
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Oxotremorine