Abstract
Results obtained with sisomycin in 10 cases of purulent meningitis and 4 of bronchopulmonitis showed good tissue diffusion, together with CSF concentrations sufficient to inhibit the main aetiological agents in these forms: MIC 0.02 mg/ml for both D. pneumoniae (I-ATCC 6301) and N. meningitidis (C-ATCC 13101), i.e. liquor transfer of the antibiotic more than sufficient to handle these agents.
MeSH terms
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Adolescent
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Adult
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Aged
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Bacteria / drug effects
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Bronchopneumonia / drug therapy*
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Child
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Drug Evaluation
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Female
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Gentamicins / therapeutic use*
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Humans
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Injections, Intramuscular
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Injections, Intravenous
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Male
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Meningitis / drug therapy*
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Meningococcal Infections / drug therapy*
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Microbial Sensitivity Tests
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Middle Aged
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Pneumococcal Infections / drug therapy*
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Sisomicin / adverse effects
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Sisomicin / metabolism
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Sisomicin / therapeutic use*