Abstract
12-O-Tetradecanoylphorbol-13-acetate promotion of skin tumors in mice can be inhibited by topical application of either the phospholipase A2 inhibitor dibromoacetophenone or the cyclooxygenase-lipoxygenase inhibitors 5,8,11,14-eicosatetrayonic acid or 1-phenyl-3-pyrazolidinone. The phospholipase A2 inhibitors in particular appear to be among the most potent inhibitors of skin tumor promotion known. These results support the hypothesis that at least some of the products of arachidonic acid transformation are essential for tumor promotion.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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5,8,11,14-Eicosatetraynoic Acid / pharmacology
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Acetophenones / pharmacology
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Animals
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Arachidonic Acids / antagonists & inhibitors
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Arachidonic Acids / metabolism*
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Biotransformation
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Female
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Male
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Mice
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Neoplasms, Experimental / chemically induced
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Neoplasms, Experimental / metabolism
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Oxygenases / antagonists & inhibitors
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Papilloma / chemically induced
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Phorbols / antagonists & inhibitors*
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Phospholipases / antagonists & inhibitors*
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Phospholipases A / antagonists & inhibitors*
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Phospholipases A2
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Prostaglandin Antagonists / pharmacology*
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Pyrazoles / pharmacology
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Skin Neoplasms / chemically induced*
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Skin Neoplasms / metabolism
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Tetradecanoylphorbol Acetate / antagonists & inhibitors*
Substances
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Acetophenones
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Arachidonic Acids
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Phorbols
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Prostaglandin Antagonists
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Pyrazoles
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5,8,11,14-Eicosatetraynoic Acid
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Oxygenases
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Phospholipases
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Phospholipases A
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Phospholipases A2
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phenidone
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Tetradecanoylphorbol Acetate