Iron absorption in iron-loading anaemias: Effect of subcutaneous desferrioxamine infusions

Lancet. 1977 Oct 8;2(8041):737-9. doi: 10.1016/s0140-6736(77)90238-0.

Abstract

Absorption of 59Fe ferrous sulphate was measured in patients with a variety of iron-loading anaemias both before and during subcutaneous infusions of desferrioxamine. The infusions were associated with a reduction in absorption (P less than 0-025). This effect was not altered by saturation with ascorbic acid.

Publication types

  • Comparative Study

MeSH terms

  • Administration, Oral
  • Adolescent
  • Adult
  • Anemia, Aplastic / metabolism*
  • Anemia, Sideroblastic / congenital
  • Anemia, Sideroblastic / metabolism*
  • Ascorbic Acid / administration & dosage
  • Ascorbic Acid / therapeutic use
  • Binding Sites
  • Blood Transfusion
  • Deferoxamine / administration & dosage*
  • Deferoxamine / therapeutic use
  • Drug Synergism
  • Erythrocytes / pathology
  • Female
  • Ferritins / blood
  • Ferrous Compounds / administration & dosage
  • Ferrous Compounds / metabolism*
  • Humans
  • Infusions, Parenteral / methods
  • Intestinal Absorption
  • Iron / metabolism*
  • Iron Radioisotopes
  • Isotope Labeling
  • Male
  • Thalassemia / metabolism*

Substances

  • Ferrous Compounds
  • Iron Radioisotopes
  • Ferritins
  • Iron
  • Deferoxamine
  • Ascorbic Acid