Massive pulmonary embolism occurring with corticosteroid and diuretics therapy in a minimal-change nephrotic patient

Nephron. 1982;32(1):78-9. doi: 10.1159/000182809.

Abstract

A 32-year-old female with a relapsing minimal-change nephrotic syndrome developed a massive pulmonary embolism during the treatment of prednisolone and diuretics. The use of diuretics in addition to a hypercoagulable state associated with nephrotic syndrome per se and corticosteroid was considered to be a direct causative factor for the event. The careful use of diuretics and a consideration of additional anticoagulant therapy are emphasized.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Disseminated Intravascular Coagulation / chemically induced
  • Dose-Response Relationship, Drug
  • Female
  • Furosemide / adverse effects*
  • Furosemide / therapeutic use
  • Heparin / therapeutic use
  • Humans
  • Nephrosis, Lipoid / drug therapy*
  • Prednisolone / adverse effects*
  • Prednisolone / therapeutic use
  • Pulmonary Embolism / chemically induced*
  • Spironolactone / adverse effects*
  • Spironolactone / therapeutic use

Substances

  • Spironolactone
  • Furosemide
  • Heparin
  • Prednisolone