Abstract
Preseasonal hyposensitization stimulated an intercorrelated increase in both serum-specific IgE and allergen-specific IgG. Subsequent perennial treatment depressed the stimulated IgE response and the basophil cell sensitivity, whereas the allergen-specific IgG response showed further increase and persisted at a high level. Nasal IgE response was stimulated from the second pollen season and subsequently became depressed. One year after the end of hyposensitization the allergen-specific IgG response had fallen by 25-50%.
Publication types
-
Clinical Trial
-
Randomized Controlled Trial
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Allergens / administration & dosage*
-
Allergens / standards
-
Antibody Specificity
-
Basophils / immunology
-
Desensitization, Immunologic*
-
Double-Blind Method
-
Female
-
Humans
-
Immunity, Cellular
-
Immunoglobulin E / biosynthesis
-
Immunoglobulin G / biosynthesis
-
Male
-
Nasal Mucosa / immunology
-
Pollen / immunology*
-
Prospective Studies
-
Reference Standards
-
Rhinitis, Allergic, Seasonal / immunology
-
Rhinitis, Allergic, Seasonal / therapy*
Substances
-
Allergens
-
Immunoglobulin G
-
Immunoglobulin E