Abstract
The plasma levels of ovarian steroids and the steroid binding capacity in the cytosol of mammary glands have been determined in the low-mammary-tumor C3H/f (XVII) mice. Implantation of a pituitary under the kidney leads to an increase of all these parameters as well as a high mammary tumor incidence. Simultaneous administration of the trans isomer of broparestrol (TBP) leads to a decrease of all the parameters.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Estradiol / metabolism
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Female
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Mammary Neoplasms, Experimental / metabolism*
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Mice
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Ovary / metabolism*
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Pituitary Gland / drug effects
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Pituitary Gland / transplantation
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Progesterone / metabolism
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Prolactin / physiology*
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Receptors, Estrogen / metabolism
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Receptors, Glucocorticoid / metabolism
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Receptors, Progesterone / metabolism
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Stilbenes / pharmacology
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Transplantation, Homologous
Substances
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Receptors, Estrogen
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Receptors, Glucocorticoid
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Receptors, Progesterone
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Stilbenes
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Progesterone
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Estradiol
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broparoestrol
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Prolactin