A potent antitumour quinazoline inhibitor of thymidylate synthetase: synthesis, biological properties and therapeutic results in mice

Eur J Cancer (1965). 1981 Jan;17(1):11-9. doi: 10.1016/0014-2964(81)90206-1.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / therapeutic use
  • Cell Survival / drug effects
  • Cells, Cultured
  • Dose-Response Relationship, Drug
  • Female
  • Folic Acid Antagonists / chemical synthesis*
  • Folic Acid Antagonists / therapeutic use
  • Folic Acid* / analogs & derivatives*
  • Leukemia L1210 / drug therapy
  • Methyltransferases / antagonists & inhibitors*
  • Mice
  • Mice, Inbred C57BL
  • Quinazolines / chemical synthesis*
  • Quinazolines / therapeutic use
  • Thymidylate Synthase / antagonists & inhibitors*

Substances

  • Antineoplastic Agents
  • Folic Acid Antagonists
  • Quinazolines
  • CB 3717
  • Folic Acid
  • Methyltransferases
  • Thymidylate Synthase