Abstract
The primary pathologic defect in Bartter's syndrome is unknown. Three patients have been studied. In two of them, with normal intra-erythrocite sodium concentration, authors prove the existence of an impaired proximal tubular sodium reabsorption. In the last case, with a high intra-erythrocite sodium concentration, this impaired sodium reabsorption was localized in the proximal and distal tubular portions.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Adult
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Bartter Syndrome / metabolism
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Bartter Syndrome / physiopathology*
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Cell Membrane Permeability
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Erythrocytes / analysis
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Erythrocytes / metabolism*
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Female
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Humans
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Hyperaldosteronism / physiopathology*
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Kidney Tubules / physiopathology*
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Kidney Tubules, Distal / metabolism
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Kidney Tubules, Distal / physiopathology*
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Male
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Osmolar Concentration
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Potassium / metabolism
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Sodium / analysis
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Sodium / metabolism*