Abstract
An in vivo electrochemical system which continuously records the concentration of metabolites of biogenic amines in small animal CSF is described. A small electrode, immersed in lateral ventricle CSF through a guide cannula, measures the amine metabolites by voltammetric oxidation. The detailed results of HVA release following electrical stimulation of the nigrostriatal pathway in rats are presented and compared with previous perfusion data. All the electrochemical results are verified by independent liquid chromatographic (chemical) analysis.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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3,4-Dihydroxyphenylacetic Acid / cerebrospinal fluid
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Animals
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Chromatography, Liquid
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Conductometry / methods
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Corpus Striatum / physiology*
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Dopamine / cerebrospinal fluid*
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Electric Stimulation / methods*
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Electrochemistry / instrumentation*
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Electrodes
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Homovanillic Acid / cerebrospinal fluid
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Hydroxyindoleacetic Acid / cerebrospinal fluid
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Male
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Neural Pathways / physiology
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Norepinephrine / cerebrospinal fluid
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Rats
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Substantia Nigra / physiology*
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Vanilmandelic Acid / cerebrospinal fluid
Substances
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3,4-Dihydroxyphenylacetic Acid
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Hydroxyindoleacetic Acid
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Vanilmandelic Acid
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Dopamine
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Norepinephrine
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Homovanillic Acid