Sialic acid metabolism in regenerating rat liver

Cancer Lett. 1981 Sep;13(4):281-9. doi: 10.1016/0304-3835(81)90055-0.

Abstract

Sialic acid metabolism was investigated in control rat liver, in regenerating liver at 24 h and 48 h after partial hepatectomy and in the liver of sham-operated animals. High levels of membrane-bound neuraminidase, with no detectable changes in the soluble enzyme, were observed in regenerating rat liver. The neuraminidase activities in the liver of sham-operated rats were identical to those present in control liver. High levels of CMP-N-acetylneuraminic acid synthetase and sialyltransferase were observed both in regenerating liver as well as in the liver of sham-operated rats. The sialic acid content of regenerating rat liver, which was lower than that found in the liver of control and sham-operated rats at 24 h, returned to normal values 48 h after surgery.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Membrane / enzymology
  • Hepatectomy
  • Liver / metabolism*
  • Liver / ultrastructure
  • Liver Regeneration*
  • Male
  • N-Acylneuraminate Cytidylyltransferase / metabolism
  • Neuraminidase / metabolism
  • Rats
  • Sialic Acids / metabolism*
  • Sialyltransferases / metabolism
  • Time Factors

Substances

  • Sialic Acids
  • Sialyltransferases
  • N-Acylneuraminate Cytidylyltransferase
  • Neuraminidase