The effect of decreased cerebral GABA levels on the development of amygdaloid kindling in rats was investigated. DL-Allylglycine, an inhibitor of glutamic acid decarboxylase (GAD), administered for 2 or 9 days (100 mg/kg and 50 mg/kg respectively) was found to accelerate the kindling process. The results are discussed according to a possible role of GABA mechanisms in the kindling phenomenon.