Abstract
An acetylenic C-glucuronide of the sedative-hypnotic drug ethchlorvynol was isolated from rabbit urine as the major metabolite. The C-glucuronide represents a novel metabolic pathway for acetylenes and is a rare example of the formation of a carbon-glucuronide bond in mammalian systems.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acetylene
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Animals
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Carbon Radioisotopes
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Ethchlorvynol / analogs & derivatives*
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Ethchlorvynol / metabolism*
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Ethchlorvynol / urine
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Glucuronidase
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Rabbits
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Spectrophotometry, Infrared
Substances
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Carbon Radioisotopes
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ethchlorvynol glucuronide
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Ethchlorvynol
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Glucuronidase
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Acetylene