Two thousand women were screened at the time of delivery for two hepatitis B markers, surface antigen (HBsAg) and antibody (HBsAb), in order to determine prevalence rates, define high-risk groups and estimate the cost-efficiency of routine screening. It was found that 2.2% of the women were HBsAg positive and 32% of a 20% subsample were HBsAb positive. Jewish women of North African origin had the highest rates (HBsAg, 3.8%; HBsAb, 47%) and those of European origin had the lowest (1.2 and 14%, respectively). Bedouin women had intermediate rates (HBsAg, 1.1%; HBsAb, 28%). The issue of screening pregnant women for HBsAg is discussed in light of these results.