Hydrostatic ultrafiltration during hemodialysis using decreasing sodium dialysate

Artif Organs. 1980 Aug;4(3):187-91. doi: 10.1111/j.1525-1594.1980.tb03932.x.

Abstract

Twelve patients underwent hemodialysis using dialysate containing 130 mEq/L sodium, and, on a separate occasion, dialysis using a dialysate of constantly decreasing sodium concentration (from 150 to 133 mEq/L). Hydrostatic ultra-filtration during dialysis was performed at a constant rate (900 ml/hr) during both treatments, and was continued until a substantial drop in mean arterial pressure (-15%) or symptoms were observed. A double-blind comparison of the two treatment modalities was thus achieved. At the end of ultrafiltration, significantly more fluid had been removed using decreasing sodium dialysate (2.9 +/- 0.3 kg) than when using the low-sodium dialysate (1.9 +/- 0.2 kg, P<0.001). Plasma sodium concentration at the end of ultrafiltration using decreasing sodium dialysate was not significantly different from the predialysis level. Hydrostatic ultrafiltration using a dialysate of decreasing sodium level may prove to be a useful means of removing excess fluid asymptomatically from dialysis patients.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Double-Blind Method
  • Humans
  • Middle Aged
  • Osmolar Concentration
  • Renal Dialysis / methods*
  • Sodium / administration & dosage*
  • Sodium / blood
  • Solutions
  • Ultrafiltration / methods*

Substances

  • Solutions
  • Sodium